Brand Name:

• 280PLUS (by TrPharma, a division of ThinkRoman Ventures LLP)

Pharmacologic Class:

• Iron Supplement
• Multivitamin

Therapeutic Use:

• Treatment and Prevention of Iron Deficiency Anemia: Helps replenish iron levels and supports red blood cell production, especially in individuals with low hemoglobin.
• Supplementation During Pregnancy: Supports increased nutritional needs, particularly iron and folic acid, to prevent anemia and birth defects associated with folic acid deficiency.
• Overall Nutritional Support: Addresses deficiencies or increased nutritional requirements due to various conditions or dietary limitations.

Mechanism of Action:

• Ferrous Ascorbate: Supplies elemental iron necessary for hemoglobin formation and red blood cell function. The ascorbate (Vitamin C) component enhances iron absorption in the gut.
• Folic Acid: A vital nutrient for DNA synthesis and cell division, essential for red blood cell production and preventing neural tube defects during pregnancy.
• Zinc: An important mineral for immune function, cell growth, wound healing, and enzyme activity. It supports various physiological processes in the body.

Dosage Forms:

• Tablets: Typically provided in blister packs or Alu-Alu packaging, with 10 strips of 15 tablets each.

Indications:

• Iron Deficiency Anemia: To replenish iron levels in patients with confirmed deficiency.
• Pregnancy-Related Anemia: To prevent anemia during pregnancy.
• General Supplementation: For individuals with increased nutritional needs or malnutrition.

Contraindications:

• Hypersensitivity to any components of the formulation.
• Iron Overload Disorders: Such as hemochromatosis or hemosiderosis.
• Non-Iron Deficiency Anemia: Should not be used for anemia that is not due to iron deficiency.

Adverse Effects:

• Common: Nausea, constipation, diarrhea, dark stools, or abdominal discomfort.
• Rare but Serious: Allergic reactions such as rash, itching, or anaphylaxis.

Drug Interactions:

• Antacids, Dairy Products, and Calcium Supplements: May interfere with iron absorption; separate dosing by at least two hours.
• Tetracyclines and Fluoroquinolones: Iron may reduce the absorption of these antibiotics.
• Folic Acid Antagonists (e.g., Methotrexate): May decrease the effectiveness of folic acid.

Special Precautions:

• Renal Impairment: Caution is advised, especially in patients with severe kidney disease.
• Gastrointestinal Conditions: Use with caution in patients with conditions like ulcerative colitis or peptic ulcers.

Pregnancy and Lactation:

• Pregnancy: Recommended during pregnancy to prevent anemia and support fetal development.
• Breastfeeding: Generally safe; the components are excreted in small amounts in breast milk.

Pediatric Use:

• Not typically recommended for children without proper medical guidance. Pediatric-specific formulations may be more appropriate.

Dosage:

• Adults: One tablet daily, or as prescribed by a healthcare professional, preferably taken with food to minimize gastrointestinal discomfort.

Storage:

• Store in a cool, dry place, away from direct sunlight.
• Keep out of reach of children to prevent accidental overdose.

Missed Dose:

• Take as soon as remembered unless it is almost time for the next dose. Do not double the dose to make up for the missed one.

Overdose:

• Symptoms may include severe gastrointestinal symptoms, fatigue, or signs of iron toxicity. Seek emergency medical attention if an overdose is suspected.

Expert Advice:

• Take with food to reduce the likelihood of stomach upset.
• Do not take with dairy or antacids within two hours to ensure optimal absorption.
• Complete the prescribed course to prevent recurrence of anemia, even if symptoms improve.

Frequently Asked Questions:

• What should I do if I experience side effects?
Report any severe or persistent symptoms, such as severe gastrointestinal discomfort or rash, to your healthcare provider.
• Can I take 280PLUS if I am already taking a multivitamin?
Consult a healthcare provider to avoid excessive intake of any nutrients, particularly iron.
• Is it safe to use during pregnancy?
Yes, it is commonly prescribed during pregnancy, but always follow your doctor’s advice.