Generic Name:

• Pantoprazole Sodium (40 mg)

Brand Name:

• AcidBlock 40 (by TrPharma, a division of ThinkRoman Ventures LLP)

Pharmacologic Class:

• Proton Pump Inhibitor (PPI)

Therapeutic Use:

• Gastroesophageal Reflux Disease (GERD): Reduces stomach acid production to help alleviate symptoms like heartburn and acid regurgitation.
• Peptic Ulcer Disease: Promotes healing of gastric and duodenal ulcers by decreasing acid secretion.
• Zollinger-Ellison Syndrome: Used to manage conditions involving excessive stomach acid production.
• Erosive Esophagitis: Helps heal inflammation and irritation of the esophagus due to acid exposure.

Mechanism of Action:

• Pantoprazole: Irreversibly inhibits the H+/K+ ATPase enzyme (proton pump) located in the gastric parietal cells, leading to a significant reduction in gastric acid secretion.

Dosage Forms:

• Tablets: Available in blister or Alu-Alu packaging, typically 10x10 tablet packs.

Indications:

• GERD with or without erosive esophagitis
• Maintenance of healing of erosive esophagitis
• Pathological hypersecretory conditions, such as Zollinger-Ellison syndrome
• Short-term treatment of gastric and duodenal ulcers

Contraindications:

• Known hypersensitivity to pantoprazole or other proton pump inhibitors.
• Co-administration with rilpivirine-containing products (an antiretroviral).

Adverse Effects:

• Common: Headache, diarrhea, nausea, abdominal pain, flatulence, dizziness.
• Serious: Rarely, hypomagnesemia, bone fracture (with long-term use), or Clostridium difficile-associated diarrhea.
• Possible Long-term Effects: Chronic use may be associated with vitamin B12 deficiency or kidney issues.

Drug Interactions:

• Clopidogrel: May reduce the antiplatelet effect; caution is advised.
• Methotrexate: High doses may result in elevated serum methotrexate levels.
• Warfarin: Monitor for increased risk of bleeding.

Special Precautions:

• Kidney and Liver Function: Caution in patients with severe hepatic or renal impairment.
• Bone Health: Long-term use may increase the risk of fractures, especially in older adults.
• Low Magnesium Levels: Monitor for symptoms such as muscle spasms, seizures, or arrhythmias during prolonged treatment.

Pregnancy and Breastfeeding:

• Pregnancy: Considered relatively safe, but use only if clearly needed.
• Breastfeeding: Excreted in human milk; caution is recommended.

Pediatric Use:

• Not generally recommended for children under 12 years unless specifically advised by a healthcare provider.

Dosage:

• Adults: Typically, one tablet (40 mg) taken once daily, before a meal.
• Dosage Adjustments: May be required in certain pathological hypersecretory conditions.

Storage:

• Store in a cool, dry place, away from direct sunlight and moisture.
• Keep out of reach of children.

Missed Dose:

• Take as soon as remembered, unless it is nearly time for the next scheduled dose. Do not double the dose.

Overdose Management:

• Symptoms may include confusion, drowsiness, or blurred vision.
• Seek immediate medical attention in case of overdose.

Expert Advice:

• Take before meals, preferably in the morning.
• Avoid long-term use unless necessary and under a doctor’s supervision.
• Do not crush or chew the tablets; swallow whole with water.

Frequently Asked Questions:

• What should I do if I still have heartburn?
Consult your healthcare provider if symptoms persist or worsen.
• Can I take AcidBlock 40 with other antacids?
Yes, but take them at least two hours apart.
• Is it safe for long-term use?
Long-term use should be regularly reviewed by a doctor, due to potential risks.