PATIENT INFORMATION LEAFLET

AcidBlock D

Pantoprazole 40 mg + Domperidone 10 mg Tablets
Brand Name: AcidBlock D
Manufacturer: TrPharma – A Division of ThinkRoman Ventures LLP
Pharmacologic Class:

• Pantoprazole: Proton Pump Inhibitor (PPI)
• Domperidone: Prokinetic / Antiemetic

1. What is AcidBlock D and What is it Used For?

AcidBlock D is a dual-action formulation that combines two active ingredients:

• Pantoprazole (40 mg): A proton pump inhibitor that reduces excess acid in the stomach.
• Domperidone (10 mg): A prokinetic that helps move food through the stomach faster, relieving bloating, nausea, and reflux.

Indications:

• Gastroesophageal Reflux Disease (GERD) with symptoms like heartburn and acid regurgitation
• Functional Dyspepsia (indigestion with bloating or early fullness)
• Nausea and vomiting associated with delayed gastric emptying
• Acid reflux with upper GI motility disorders
• Postprandial fullness and discomfort

2. How Does AcidBlock D Work?

• Pantoprazole irreversibly blocks the H⁺/K⁺ ATPase (proton pump) in the stomach’s parietal cells, significantly reducing acid secretion.
• Domperidone works by blocking dopamine (D2) receptors in the GI tract, enhancing the movement of food through the stomach and intestines while also reducing nausea and vomiting.

Together, they provide rapid and sustained relief from acidity, reflux, bloating, and gas-related symptoms.

3. Dosage and Administration

• Usual Adult Dose: One tablet daily, preferably 15–30 minutes before a meal (usually before breakfast).
• Do Not: Crush or chew the tablet. Swallow it whole with water.
• Missed Dose: Take it when remembered unless close to the next dose. Do not double the dose.
• Overdose: Seek immediate medical attention. Symptoms may include confusion, dizziness, or irregular heartbeat.

4. Dosage Form and Packaging

• Tablet: Each film-coated tablet contains:
  • Pantoprazole Sodium (equiv. to 40 mg Pantoprazole)
  • Domperidone 10 mg
• Pack Size: Blister or Alu-Alu pack of 10x15 tablets.

5. Warnings and Precautions

• Do not use if allergic to pantoprazole, domperidone, or other PPIs.
• Avoid use if you have:
  • Heart rhythm problems (QT prolongation)
  • Moderate to severe liver disease
  • Gastrointestinal bleeding or blockage

Use with caution in:

• Patients with kidney or liver disease
• Older adults, due to potential risk of cardiac effects from domperidone
• Pregnancy: Use only if clearly needed
• Breastfeeding: Not recommended due to domperidone excretion in milk

6. Side Effects

Common:

• Headache
• Diarrhea or constipation
• Nausea
• Abdominal pain
• Dry mouth
• Dizziness

Serious/Rare:

• Irregular heartbeat (especially with domperidone in high doses)
• Low magnesium levels (with long-term pantoprazole use)
• Allergic reactions
• Vitamin B12 deficiency (long-term)

7. Drug Interactions

Inform your doctor if you are taking:

• Antacids – allow 1–2 hours gap
• Clopidogrel – pantoprazole may reduce its efficacy
• Ketoconazole, iron supplements – absorption may be reduced
• CNS drugs (e.g., levodopa) – domperidone may interact
• Erythromycin or antifungals – may increase domperidone side effects
• Rilpivirine or HIV meds – contraindicated

8. Storage

• Store in a cool, dry place, away from direct sunlight and moisture
• Keep out of reach of children
• Do not use after the expiry date

9. Frequently Asked Questions (FAQs)

Q: Can I take AcidBlock D for regular gas and heartburn?
A: Yes, it is commonly used for reflux, bloating, and post-meal acidity.

Q: Can I take this long-term?
A: Long-term use should be under a doctor’s supervision, especially due to potential nutrient imbalances and cardiac risks.

Q: Can I take it with food?
A: It is best taken before a meal, preferably in the morning.

Q: Can I take antacids with it?
A: Yes, but leave a 1–2 hour gap between doses.

10. Expert Advice

• Take before meals for best effect
• Do not exceed the recommended dose
• Do not use for more than 4 weeks without consulting a healthcare provider
• Monitor symptoms; seek medical review if symptoms persist or worsen
• Stay hydrated and follow dietary modifications for better results

TrPharma, A Division of ThinkRoman Ventures LLP
For more information, consult your physician or pharmacist.