Generic Name

Levocetirizine Hydrochloride 5 mg
Montelukast Sodium 10 mg

Brand Name

KashAIR-M
(by TrPharma, a division of ThinkRoman Ventures LLP)

Pharmacologic Class

• Antihistamine (Second-generation H1 receptor antagonist)
• Leukotriene Receptor Antagonist

Therapeutic Use

Treatment of Allergic Conditions:
Used for the management of allergic rhinitis, seasonal and perennial allergies, and allergy-associated respiratory symptoms.

Combination Therapy Advantage:
Levocetirizine provides rapid antihistamine relief, while montelukast controls leukotriene-mediated inflammation, offering comprehensive symptom control.

Mechanism of Action

Levocetirizine:
A selective H1 receptor antagonist that inhibits the action of histamine, reducing sneezing, itching, rhinorrhea, and watery eyes.

Montelukast:
A leukotriene receptor antagonist that blocks cysteinyl leukotrienes (LTD4) in the airways, decreasing inflammation, bronchoconstriction, and mucus production.

Dosage Forms

Tablets:
Supplied in Alu-Alu packaging (10 × 10 tablets).

Indications

• Allergic Rhinitis:
  Seasonal and perennial
• Chronic Allergic Conditions
• Allergy-Associated Cough
• Adjunct Therapy in Mild Asthma
• Upper Respiratory Allergic Symptoms

Contraindications

• Known hypersensitivity to levocetirizine, montelukast, or any component of the formulation
• Severe renal impairment (levocetirizine component)

Adverse Effects

Common:
Drowsiness, headache, dry mouth, fatigue, abdominal discomfort.

Serious (Rare):
Neuropsychiatric symptoms (e.g., agitation, mood changes), hypersensitivity reactions, elevated liver enzymes.

Drug Interactions

• CNS Depressants: May enhance drowsiness
• Alcohol: Increased risk of sedation
• Enzyme Inducers (e.g., rifampicin): May reduce montelukast levels

Special Precautions

• Use caution in patients with renal impairment
• Monitor for neuropsychiatric symptoms during montelukast therapy
• Not intended for acute asthma attacks

Pregnancy and Breastfeeding

Pregnancy:
Use only if clearly needed and prescribed by a healthcare professional.

Breastfeeding:
Levocetirizine may be excreted in breast milk; use with caution.

Pediatric Use

Dosage adjustments are required based on age and weight.
Pediatric formulations may be used as directed by a physician.

Dosage

Adults:
Typically, one tablet once daily, preferably in the evening, or as directed by a healthcare professional.

Adjustments:
Required in patients with renal impairment.

Storage

Store in a cool, dry place, away from direct sunlight and moisture.
Keep out of reach of children.

Missed Dose

Take as soon as remembered, unless it is almost time for the next scheduled dose.
Do not double the dose.

Overdose Management

Symptoms may include excessive drowsiness, agitation, or gastrointestinal upset.
Seek immediate medical attention in case of suspected overdose.

Expert Advice

Take preferably in the evening to minimize daytime drowsiness.
Avoid alcohol while on treatment.
Use regularly for optimal allergy control during exposure periods.

Frequently Asked Questions

What should I do if I experience excessive drowsiness or mood changes?
Discontinue use and consult a healthcare provider immediately.

Can KashAIR-M be taken long-term?
Yes, under medical supervision for chronic allergic conditions.

Is KashAIR-M safe for asthma patients?
It may be used as adjunct therapy but is not a substitute for rescue inhalers.