Generic Name

Cefixime 200 mg

Brand Name

KashEFX 200
(by TrPharma, a division of ThinkRoman Ventures LLP)

Pharmacologic Class

• Third-Generation Cephalosporin Antibiotic
• Beta-lactam Antibiotic

Therapeutic Use

Treatment of Bacterial Infections:
Used for treating a range of bacterial infections, particularly those involving the respiratory tract, urinary tract, ear, and gastrointestinal system.

Broad-Spectrum Activity:
Effective against Gram-positive and Gram-negative organisms, including beta-lactamase–producing bacteria.

Mechanism of Action

Cefixime:
A third-generation cephalosporin that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), resulting in bacterial cell lysis and death.

Cefixime is stable against many beta-lactamases, allowing activity against resistant strains.

Dosage Forms

Dispersible Tablets:
200 mg, supplied in Alu-Alu packaging (10 × 10 tablets).

Indications

• Respiratory Tract Infections:
  Acute bronchitis, pharyngitis, tonsillitis
• Ear Infections (Otitis Media)
• Urinary Tract Infections (UTIs)
• Typhoid Fever
• Gastrointestinal Infections:
  Caused by susceptible organisms

Contraindications

• Known hypersensitivity to cephalosporins
• History of severe hypersensitivity reactions to penicillins or other beta-lactam antibiotics

Adverse Effects

Common:
Diarrhea, nausea, abdominal pain, dyspepsia, headache.

Serious (Rare):
Severe allergic reactions, Clostridium difficile–associated diarrhea, liver enzyme elevations.

Drug Interactions

• Anticoagulants (e.g., warfarin): Increased bleeding risk
• Carbamazepine: Increased serum levels
• Antacids: May reduce absorption if taken together

Special Precautions

• Use with caution in patients with a history of gastrointestinal disease, especially colitis
• Monitor renal function in patients with renal impairment
• Prolonged use may result in superinfection

Pregnancy and Breastfeeding

Pregnancy:
Generally considered safe when prescribed by a healthcare professional.

Breastfeeding:
Excreted in small amounts in breast milk; usually considered safe, though mild gastrointestinal disturbances in the infant may occur.

Pediatric Use

Dosage adjustments are required based on body weight and severity of infection.
Dispersible tablets are suitable for pediatric use as directed by a physician.

Dosage

Adults:
Typically, 200 mg once or twice daily, or as directed by a healthcare professional.

Adjustments:
Required in patients with renal impairment.

Storage

Store in a cool, dry place, away from direct sunlight and moisture.
Keep out of reach of children.

Missed Dose

Take as soon as remembered, unless it is almost time for the next scheduled dose.
Do not double the dose.

Overdose Management

Symptoms may include severe gastrointestinal upset, dizziness, or neurological symptoms.
Seek immediate medical attention in case of suspected overdose.

Expert Advice

Complete the full course of treatment, even if symptoms resolve early.
Disperse the tablet in water before administration as directed.
Stay hydrated to minimize gastrointestinal side effects.

Frequently Asked Questions

What should I do if I experience severe side effects?
Discontinue use and consult a healthcare provider immediately if severe diarrhea, rash, or allergic reactions occur.

Can KashEFX 200 be taken with food?
Yes, it may be taken with or without food.

Is alcohol consumption safe during treatment?
Avoid alcohol, as it may worsen side effects and delay recovery.