Generic Name

Azithromycin 500 mg

Brand Name

KashZEE 500
(by TrPharma, a division of ThinkRoman Ventures LLP)

Pharmacologic Class

• Macrolide Antibiotic
• Azalide Antibiotic

Therapeutic Use

Treatment of Bacterial Infections:
Used for treating a variety of bacterial infections, including those of the respiratory tract, ear, sinus, skin, soft tissues, and certain sexually transmitted infections.

Broad-Spectrum Activity:
Effective against Gram-positive, Gram-negative, and atypical organisms, including intracellular pathogens.

Mechanism of Action

Azithromycin:
A macrolide antibiotic that works by inhibiting bacterial protein synthesis through binding to the 50S ribosomal subunit. This prevents bacterial growth and replication, leading to resolution of infection.

Azithromycin achieves high tissue and intracellular concentrations, allowing once-daily dosing and shorter treatment duration.

Dosage Forms

Tablets:
500 mg, supplied in Alu-Alu packaging (10 × 5 tablets).

Indications

• Respiratory Tract Infections:
  Bronchitis, community-acquired pneumonia, pharyngitis, tonsillitis
• ENT Infections:
  Sinusitis, otitis media
• Skin and Soft Tissue Infections
• Sexually Transmitted Infections:
  Uncomplicated Chlamydia trachomatis
• Atypical Infections:
  Caused by Mycoplasma, Chlamydia, and Legionella species

Contraindications

• Known hypersensitivity to azithromycin, erythromycin, or other macrolide antibiotics
• History of cholestatic jaundice or hepatic dysfunction associated with azithromycin use

Adverse Effects

Common:
Diarrhea, nausea, abdominal pain, vomiting, headache.

Serious (Rare):
Severe allergic reactions (including anaphylaxis), QT prolongation, cardiac arrhythmias, liver dysfunction, Clostridium difficile-associated diarrhea.

Drug Interactions

• Antacids (Aluminum/Magnesium): May reduce absorption
• Anticoagulants (e.g., warfarin): May enhance anticoagulant effect
• Digoxin: Increased serum levels possible
• Antiarrhythmic drugs: Increased risk of QT prolongation

Special Precautions

• Use with caution in patients with known cardiac arrhythmias or prolonged QT interval
• Monitor liver function in patients with hepatic impairment
• Use only for confirmed or strongly suspected bacterial infections

Pregnancy and Breastfeeding

Pregnancy:
Generally considered safe when prescribed by a healthcare professional.

Breastfeeding:
Excreted in small amounts in breast milk; usually safe, though mild gastrointestinal disturbances in the infant may occur.

Pediatric Use

Dosage adjustments are required based on body weight and severity of infection. Pediatric formulations may be used where indicated.

Dosage

Adults:
Typically, one tablet (500 mg) once daily for 3–5 days, or as directed by a healthcare professional.

Adjustments:
Use with caution in hepatic impairment. Dose adjustment is generally not required in renal impairment.

Storage

Store in a cool, dry place, away from direct sunlight and moisture.
Keep out of reach of children.

Missed Dose

Take as soon as remembered, unless it is almost time for the next scheduled dose.
Do not double the dose.

Overdose Management

Symptoms may include severe gastrointestinal upset and, rarely, reversible hearing impairment.
Seek immediate medical attention in case of suspected overdose.

Expert Advice

Complete the full course of treatment, even if symptoms resolve early.
May be taken with or without food; taking with food can reduce stomach discomfort.
Avoid unnecessary antibiotic use to reduce the risk of resistance.

Frequently Asked Questions

What should I do if I experience severe side effects?
Discontinue use and consult a healthcare provider immediately if severe side effects such as rash, palpitations, or persistent diarrhea occur.

Can I take KashZEE 500 on an empty stomach?
Yes, but taking it with food may help reduce gastrointestinal discomfort.

Is alcohol consumption safe during treatment?
Avoid alcohol, as it may worsen side effects and delay recovery.