Product Name: One87 Plus

Manufacturer: TrPharma- A Division of ThinkRoman ventures LLP

Composition: Aceclofenac 100 mg and Paracetamol 325 mg

Packing Type: Blister or strip packaging

Packaging: Available in strips containing 10 tablets each, but this may vary.

Schedule: Schedule H (Prescription drug)

Usage: Used for the relief of pain and inflammation in conditions like osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis.

Mechanism of Action: Aceclofenac works by inhibiting the cyclooxygenase (COX) enzymes which are involved in the synthesis of prostaglandins, thereby reducing inflammation and pain. Paracetamol acts centrally in the brain, inhibiting prostaglandin synthesis and providing analgesic and antipyretic effects.

Pharmacokinetics:

• Aceclofenac: Well absorbed orally with a half-life of around 4 hours. It is extensively bound to plasma proteins and metabolized in the liver.
• Paracetamol: Rapidly absorbed from the gastrointestinal tract with a half-life of 1-4 hours. It undergoes hepatic metabolism.

Side Effects: Nausea, vomiting, stomach pain, diarrhea, heartburn, dizziness, allergic reactions, and rash.

Contra-indications: Hypersensitivity to aceclofenac, paracetamol, or any NSAIDs; peptic ulcer disease; severe renal or hepatic impairment.

Special Precautions: Use with caution in patients with cardiovascular disease, gastrointestinal disorders, or asthma. Monitor liver and kidney function in long-term use.

Pregnancy Related Information: Not recommended during pregnancy, particularly in the third trimester, unless absolutely necessary. Should be taken only upon consultation with a healthcare provider.

Breast Feeding Related Information: Use with caution while breastfeeding. Limited data suggests low risk, but it is important to consult a healthcare provider.

Children Related Information: Dose adjustment may be needed; consult a pediatrician. Avoid under 12 years unless prescribed.

Interactions: May interact with blood thinners (e.g., warfarin), other NSAIDs, liver enzyme-inducing drugs (e.g., alcohol or barbiturates), and certain antihypertensives.

Typical Dosage: Usually, one tablet two to three times a day, depending on the severity of the condition and as prescribed by a healthcare provider.

Storage Requirements: Store in a cool, dry place away from sunlight. Keep out of reach of children.

Effects of Missed Dosage: Take the missed dose as soon as you remember unless it is close to the time of your next dose. Do not double the dose to catch up.

Effects of Overdose: Symptoms may include nausea, vomiting, stomach pain, drowsiness, headache, and confusion. Seek immediate medical attention in case of an overdose.

Expert Advice: Do not consume alcohol while taking this medication, as it can increase the risk of liver damage. Regularly monitor liver function if used for extended periods.

FAQs

Q: Can I take One87 Plus for a headache or fever?

• A: Yes, paracetamol in One87 Plus can help alleviate fever and mild headache, but there are simpler formulations available that might be more suitable. Always consult a healthcare provider first.

Q: Is One87 Plus addictive or habit-forming?

• A: No, One87 Plus is not known to cause dependence or addiction.

Q: Can I take One87 Plus with other painkillers?

• A: Avoid combining it with other NSAIDs or paracetamol-containing medicines unless advised by a healthcare provider to prevent overdose or adverse effects.

Q: How long can I safely use One87 Plus?

• A: For acute conditions, use should be limited to the shortest duration necessary. For chronic conditions like arthritis, consult your healthcare provider for ongoing management.

Q: What should I do if I experience side effects?

• A: Discontinue use and seek medical advice immediately if you experience severe side effects like difficulty breathing, severe rash, or signs of liver damage (e.g., yellowing of skin/eyes).