Generic Name

Progesterone 200 mg

Brand Name

Progestasyn® 200
(by TrPharma, a division of ThinkRoman Ventures LLP)

Pharmacologic Class

• Progestogen
• Natural Progesterone Hormone

Therapeutic Use

Hormonal Support Therapy:
Used for progesterone supplementation in conditions associated with progesterone deficiency.

Gynecological and Obstetric Use:
Supports luteal phase, early pregnancy, and hormone balance in reproductive health.

Mechanism of Action

Progesterone:
A naturally occurring hormone that prepares the endometrium for implantation and maintains pregnancy by reducing uterine contractility and supporting endometrial stability.

Progesterone also counteracts estrogen-induced endometrial proliferation, helping maintain hormonal balance.

Dosage Forms

Soft Gelatin Capsules:
200 mg, supplied in blister packaging.

Routes of Administration:

• Vaginal
• Rectal
• Oral (as directed by physician)

Indications

• Luteal Phase Deficiency
• Threatened or Recurrent Miscarriage (as adjunct therapy)
• Assisted Reproductive Techniques (ART / IVF support)
• Hormone Replacement Therapy (with estrogen)
• Menstrual Disorders due to Progesterone Deficiency

Contraindications

• Known hypersensitivity to progesterone or any component of the formulation
• Undiagnosed vaginal bleeding
• Severe hepatic dysfunction
• Known or suspected hormone-dependent malignancy (unless advised by specialist)

Adverse Effects

Common:
Drowsiness, dizziness, headache, breast tenderness, bloating.

Occasional:
Nausea, abdominal discomfort, vaginal irritation (with vaginal use).

Serious (Rare):
Allergic reactions, mood changes, visual disturbances.

Drug Interactions

• CNS Depressants: Increased sedation
• Enzyme Inducers (e.g., rifampicin, phenytoin): May reduce progesterone effectiveness
• Hormonal Therapies: Use under medical supervision

Special Precautions

• Use with caution in patients with liver disease, depression, or thromboembolic disorders
• Monitor during prolonged use
• Not intended for contraceptive use

Pregnancy and Breastfeeding

Pregnancy:
Widely used and considered safe when prescribed by a healthcare professional for luteal support and pregnancy maintenance.

Breastfeeding:
Use only if clearly indicated and advised by a physician.

Pediatric Use

Not indicated for pediatric use.

Dosage

Adults:
Typically, 200 mg once or twice daily, depending on indication, route of administration, and clinical judgment.

Adjustments:
Dose and duration should be individualized based on patient response and indication.

Storage

Store below 30°C, protected from light and moisture.
Keep out of reach of children.

Missed Dose

Take as soon as remembered unless it is almost time for the next scheduled dose.
Do not double the dose.

Overdose Management

Symptoms may include excessive drowsiness, dizziness, or gastrointestinal discomfort.
Seek medical advice in case of suspected overdose.

Expert Advice

Use strictly as prescribed by your healthcare provider.
Route of administration should be followed exactly as advised.
Report unusual bleeding, severe drowsiness, or mood changes promptly.

Frequently Asked Questions

Can Progestasyn® 200 be used during pregnancy?
Yes, when prescribed by a healthcare professional for progesterone support.

Can it cause drowsiness?
Yes. Taking the dose at bedtime is often recommended.

Is long-term use safe?
Long-term use should be under medical supervision.